Newsletter, November 2017
Volume 1, Issue 2
Dementia affects one-third of all people older than 65 years in the United States. The most common cause of dementia is Alzheimer鈥檚 disease, a progressive, irreversible brain disease that results in impaired cognitive functioning and other behavioral changes. Humans are considered uniquely susceptible to Alzheimer鈥檚 disease, potentially due to genetic differences, changes in brain structure and function during evolution, and an increased lifespan.
However, a published Aug. 1 in provides the most extensive evidence of Alzheimer鈥檚 disease brain pathology in a primate species to date. Researchers from Kent State University鈥檚 College of Arts and Sciences, along with colleagues from the George Washington University, Yerkes National Primate Research Center, Georgia State University, Barrow Neurological Institute and the Icahn School of Medicine at Mount Sinai, found that the brains of aged chimpanzees, our closest living relatives, show pathology similar to the human Alzheimer鈥檚 disease brain.
This research adds to a growing number of studies using an evolutionary perspective to identify differences between humans and chimpanzees that could lead to potential targets for therapeutic interventions in humans.
鈥淰ery few studies have investigated Alzheimer鈥檚 disease pathology in chimpanzees, the species closest in phylogeny and most genetically related to humans,鈥 said senior author Mary Ann Raghanti, Ph.D., associate professor and interim chair of anthropology at Kent State. 鈥淏rain samples from great apes, particularly aged individuals, are incredibly scarce, so a study of this size is rare.鈥
Dysfunction of two proteins, amyloid beta and tau, plays a role in the development of Alzheimer鈥檚 disease. In healthy brains, amyloid beta is degraded and eliminated, but in Alzheimer鈥檚 disease, overproduction and disrupted clearance of the protein results in the formation of plaques between brain cells called neurons. Amyloid beta in the form of insoluble plaques and soluble peptides initiates changes in tau, another protein found mostly in neurons, that destabilizes the cell鈥檚 skeleton. In Alzheimer鈥檚 disease, alterations in tau lead to the formation of neurofibrillary tangles and cell death. These neuronal changes result in the onset of dementia.
Analysis of the brain samples for this study began in 2013 in Raghanti鈥檚 lab at Kent State. The brains were provided by the , which collects the brains of chimpanzees that have died from natural causes at zoos and research centers. The collection started in the mid-1990s for what was then called the Great Ape Aging Project. The National Chimpanzee Brain Resource is supported by the National Institutes of Health (NIH) and is operated in partnership by the George Washington University, Georgia State and Yerkes National Primate Research Center.
By examining brain regions most affected by Alzheimer鈥檚 disease pathology in humans, the group demonstrated that amyloid beta plaques and blood vessels were present in all 20 aged chimpanzee brains. Similar to humans, increasingly larger volumes of amyloid beta plaques and blood vessels were found with greater age.
鈥淚nterestingly, though, amyloid beta deposition was higher in blood vessels than in plaques, and this correlated with increases in tau lesions,鈥 said Melissa Edler, Ph.D., lead author and former doctoral student in biomedical sciences at Kent State. 鈥淭his suggests that amyloid buildup in the brain鈥檚 blood vessels precedes plaque formation in chimpanzees.鈥
These findings differ from what we see in humans. While approximately 80 percent of Alzheimer鈥檚 disease patients also have cerebral amyloid angiopathy, or amyloid beta deposits in the brain鈥檚 blood vessels that increase the risk for stroke and dementia, the predominant amyloid beta pathology is plaques. Tau lesions also were found in the forms of neurofibrillary tangles and clusters of tau-positive neurites (i.e., pieces of dying neurons).
鈥淣eurofibrillary tangles are observed in Alzheimer鈥檚 disease patients, but the tau-immunoreactive neuritic clusters in the neocortex appear specific to chimpanzees,鈥 said Patrick R. Hof, M.D., Regenstreif professor and vice-chair of neuroscience at Icahn School of Medicine at Mount Sinai. In addition, neurofibrillary tangles pathology was observed in apes that exhibited plaques and moderate or severe cerebral amyloid angiopathy and in one individual with virtually no amyloid beta pathology. 鈥淭he presence of amyloid and tau pathology in aged chimpanzees indicates these Alzheimer鈥檚 disease lesions are not specific to the human brain as generally believed,鈥 Hof continued.
鈥淲hether these pathologies play a key role in age-related cognitive decline requires continued investigation of this species,鈥 said Elliott Mufson, Ph.D., professor and Greening Chair in Aging at the Barrow Neurological Institute.
鈥淲e initiated the Great Ape Aging Project 20 years ago because we saw an aging chimpanzee population under human care that would need geriatric attention for disorders similar to those affecting aging humans,鈥 said Joseph Erwin, Ph.D., research professor of anthropology at the George Washington University.
鈥淔indings like those reported in this paper provide significant evidence of the value and need for continued behavioral, cognitive and neurogenomic work with this important species,鈥 said William D. Hopkins, Ph.D., professor of neuroscience at Georgia State and associate research scientist at Yerkes National Primate Research Center, Emory University.
鈥淭his study confirms the value of a 鈥樷 approach to gerontology and the neurobiology of aging for the benefit of humans and apes,鈥 Erwin added.
The article is titled 鈥淎ged Chimpanzees Exhibit Pathologic Hallmarks of Alzheimer鈥檚 Disease鈥 by Melissa K. Edler, Ph.D.; Chet C. Sherwood, Ph.D.; Richard S. Meindl, Ph.D.; William D. Hopkins, Ph.D.; John J. Ely, Ph.D.; Joseph M. Erwin; Elliott J. Mufson, Ph.D.; Patrick R. Hof, M.D.; and Mary Ann Raghanti, Ph.D (). It appears in Neurobiology of Aging, published by .
This research was supported by grants from the National Science Foundation (BCS-1316829 to M.A.R.), NIH (NS042867, NS073134, and NS092988 to W.D.H. and C.C.S.; AG017802 to J.J.E.; AG014308 to J.M.E.; AG005138 to P.R.H.; AG014449 and AG043775 to E.J.M.), James S. McDonnell Foundation (220020293 to C.C.S.), Sigma Xi, the Kent State University Research Council and Kent State鈥檚 Graduate Student Senate.
Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age.
For more information about Kent State鈥檚 Department of Anthropology, visit www.kent.edu/anthropology.
For more information about research at Kent State, visit www.kent.edu/research.
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Photo Caption:
Kent State University researchers analyzed the brains of aged chimpanzees to show pathology similar to the human Alzheimer鈥檚 disease brain. This image shows tau-positive neuron (black) in proximity to amyloid deposits within blood vessels (red) in an aged chimpanzee brain.
Media Contacts:
Mary Ann Raghanti, mraghant@kent.edu, 330-672-9354
Emily Vincent, evincen2@kent.edu, 330-672-8595
Return to NOVEMBER 2017 Newsletter
WORLD FIRST: NEW POLYMER GOES FOR A WALK WHEN ILLUMINATED
KENT STATE GEOGRAPHERS RECEIVE TWO RESEARCH GRANTS TO STUDY CLIMATE CHANGE AND WEATHER PATTERNS
KENT STATE RESEARCHER EXAMINES VACCINE REJECTION AND HESITANCY
Scientists at Eindhoven University of Technology in the Netherlands and Kent State University have developed a new material that can undulate and therefore propel itself forward under the influence of light. To achieve this, the scientists clamp a strip of this polymer material in a rectangular frame. When illuminated, it goes for a walk all on its own. This small device, the size of a paperclip, is the world鈥檚 first machine to convert light directly into walking, simply using one fixed light source. The researchers, including Professor Robin Selinger of Kent State鈥檚 Liquid Crystal Institute庐 in the College of Arts and Sciences, published their findings on June 29 in the scientific journal Nature.
The maximum speed of the device is equivalent to that of a caterpillar, about half a centimeter per second. The researchers think it can be used to transport small items in hard-to-reach places or to keep the surface of solar cells clean. The researchers placed grains of sand on the strip, and these were removed by the undulating movement. The mechanism is so powerful that the strip can even transport an object that is much bigger and heavier than the device itself uphill.
The motion of the new material is due to the fact that one side contracts in reaction to light while the other side expands, causing it to bulge when illuminated. That deformation disappears instantaneously once the light is gone. Although the material looks transparent to the human eye, it fully absorbs the violet light the researchers used, thus creating a shadow behind it.Scientists at Eindhoven University of Technology in the Netherlands and Kent State University in Ohio have developed a new material that can undulate and therefore propel itself forward under the influence of light. (Photo credit: Bart van Overbeeke)
The scientific team, led by Professor Dick Broer of Eindhoven University of Technology, was able to create a continual undulating movement, using this 鈥渟elf-shadowing鈥 effect. The team members attached a strip of the material in a frame shorter than the strip itself, causing it to bulge. Then the researchers shone a concentrated LED light on it from in front. The part of the strip that is in the light starts to bulge downward, creating a 鈥渄ent鈥 in the strip. As a consequence, the next part of the strip comes in the light and starts to deform. This way, the 鈥渄ent鈥 moves backward, creating a continual undulating movement. This sets the device in motion, walking away from the light. When the device is placed upside down, the wave travels in the opposite direction, causing it to walk toward the light.
The research team managed to reach this specific behavior of the material using liquid crystals, familiar in liquid crystal displays or LCDs. The principle relies on the incorporation of a fast-responding, light-sensitive variant in a liquid crystalline polymer network. The researchers engineered a material in such a way that this response is translated to an instantaneous deformation of the strip when illuminated and relaxation when the light is gone. Computer simulations demonstrated the self-shadowing mechanism and explained the directionality of light-driven motion.
The research team鈥檚 paper in Nature is titled 鈥淢aking Waves in a Photoactive Polymer Film.鈥 Joining Selinger and Broer as authors are Anne H茅l猫ne G茅l茅bart, Dirk Jan Mulder, Ghislaine Vantomme and Bert Meijer of Eindhoven University of Technology and Michael Varga and Andrew Konya of Kent State. The empirical study took place at Eindhoven University of Technology with the corresponding theoretical model being developed at Kent State. The research was made possible by subsidies from the Dutch research funding agency NOW, the European Research Council and grants from the U.S. National Science Foundation.
For more information about Eindhoven University of Technology, visit .
For more information about Kent State鈥檚 Liquid Crystal Institute, visit .
Return to NOVEMBER 2017 Newsletter
KENT STATE RESEARCHERS HELP FIND PATHOLOGIC HALLMARKS OF ALZHEIMER鈥橲 DISEASE IN AGED CHIMPANZEE BRAINS
KENT STATE GEOGRAPHERS RECEIVE TWO RESEARCH GRANTS TO STUDY CLIMATE CHANGE AND WEATHER PATTERNS
KENT STATE RESEARCHER EXAMINES VACCINE REJECTION AND HESITANCY
The center of a public health debate is whether parents should have their children vaccinated. Tara Smith, Ph.D., professor of epidemiology at Kent State University鈥檚 College of Public Health, challenges statements made by influential individuals who oppose the widespread use of vaccines, and she calls upon her colleagues in the scientific community to speak out to promote vaccination.
The article, 鈥,鈥 is published by Oxford Press鈥 Open Forum Infectious Diseases. In the July 18 article, Smith presents clear and scientifically based arguments to explain why anti-vaccination statements are inaccurate, misleading and even disingenuous. As a recognized expert in microbiology of infectious disease, her concern is that the public can become confused about the safety of vaccines and may be hesitant to immunize themselves and their children.
Widespread refusal of vaccines could lead to many more people becoming infected with vaccine-preventable diseases, such as measles, mumps and influenza.
鈥淭hough there is scant evidence that refusal is genuinely increasing in the population, multiple studies have demonstrated concerning patterns of decline of confidence in vaccines, the medical professionals who administer vaccines and the scientists who study and develop vaccines,鈥 Smith wrote.
Her article presents reliable information about vaccine safety while debunking myths that are being circulated and creating misunderstandings among the general public. The article also presents ways that healthcare and infectious disease professionals can actively promote vaccination to friends, family and the people they serve. This information is presented in a way that is sensitive to scientifically trained professionals鈥 reluctance to advocate on issues in black-and-white terms while also recognizing what is at stake if they do not take action.
For more information about Smith鈥檚 research, visit www.kent.edu/publichealth/profile/tara-c-smith-phd.
For more information about Kent State鈥檚 College of Public Health, visit www.kent.edu/publichealth.
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Photo Caption:
Tara Smith, Ph.D., professor of epidemiology at Kent State University鈥檚 College of Public Health, challenges statements made by influential individuals who oppose the widespread use of vaccines, and she calls upon her colleagues in the scientific community to speak out to promote vaccination.
Media Contacts:
Tara Smith, tsmit176@kent.edu, 330-672-3946
Emily Vincent, evincen2@kent.edu, 330-672-8595
Return to NOVEMBER 2017 Newsletter
KENT STATE RESEARCHERS HELP FIND PATHOLOGIC HALLMARKS OF ALZHEIMER鈥橲 DISEASE IN AGED CHIMPANZEE BRAINS
KENT STATE GEOGRAPHERS RECEIVE TWO RESEARCH GRANTS TO STUDY CLIMATE CHANGE AND WEATHER PATTERNS
WORLD FIRST: NEW POLYMER GOES FOR A WALK WHEN ILLUMINATED